Two cases of anaplastic large cell lymphoma and nodular sclerosis type Hodgkin's disease - A comparison in cytologic features of tumor cells in lymph nodes.:A comparison in cytologic features of tumor cells in lymph nodes

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Background: We treated 2 cases of anaplastic large cell lymphoma (ALCL) and nodular sclerosis Hodgkin's disease (NS-HD). It remains difficult to differentiate ALCL from NS-HD histopathologically without immunohistochemical techniques. We compared the cytological features of tumor cells in lymph nodes from patients using imprint cytology. Results: The following differences were found between the 2 diseases: 1) Tumor cells mutually adhered to form a mass in ALCL, whereas lacunar cells were diffuse and inflammatory cells, such as small lymphocytes, occurred in the background in NS-HD, 2) In ALCL, tumor cells were large but relatively even in site, whereas lacunar cells in NS-HD were larger and sizes varied markedly, 3) Nuclear polymorphism and hyperchromatism were more pronounced in lacunar cells. 4) In ALCL, Reed-Sternberg (RS)-like cells were observed to have 2 nuclei, whereas Hodgkin cells and RS cells in NS-HD were larger and accompanied by a perinucleolar halo, 5) Large numbers of tumor cells having a typical doughnut-shaped nucleus were detected in ALCL but hardly any in NS-HD. Conclusions: The above differences may provide valuable cytological information in the differential diagnosis of ALCL and NS-HD.
特定非営利活動法人日本臨床細胞学会の論文