Cytological features in 6 cases of glassy cell carcinoma of the uterine cervix.
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概要
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<B><I>Objective</I>:</B> Glassy cell carcinoma (GCC) is rare in uterine cervical carcinoma. Cytological findings of GCC have not been fully clavified.<BR><B><I>Study design</I>:</B> Six cases of GCC were seen from 1994 to 2000 in our department. Mean age of patients was 54.5 year old (38 to 75 years). Patients mainly reported abnormal genital bleeding. The clinical stage of was Ib 2 in 1, II a in 1, IIb in 1 and IIIb in 2. Five were treated by radical hysterectomy. One patient died of cancer soon after biopsy and therapy. In initial cytological examination, GCC was diagnosed in 4 and large cell nonkeratinizing squamous cell carcinoma in 2. GCC was diagnosed in 5 hysterectomy specimens and one biopsy specimen histologically.<BR><B><I>Results</I>:</B> Cytologically tumor cells showed polygonal, nuclear pleomorphism and often a giant cell pattern. Their cytoplasm was finely granular and abundant. Nuclei showed a large, oval, hyperchromatic and irregular peripheral configuration. The chromatin pattern of nuclei showed a coarsely granular and irregular distribution, and nucleoli were prominant and multiple in a bizarre nucleus. There was no evidence of tubulo-papillary structure or keratinization. Cytological characteristics were compatible with histological findings.<BR><B><I>Conclusiton</I>:</B> Cytologically, GCC showed polyhedral cells, cellular pleomorphism, large ovoid nuclei with prominent nucleoli and finely granular cytoplasm, which must be important in diagnosing GCC cytologically and it is important to keep this in mind when cytologically diagnosing uterine cervical tumors.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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