The standard method for the preparation to turn the automated cytology.
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概要
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<B><I>Purpose</I>:</B> Standardized preparation is desirable in cytology, due to the use of different devices. The remains problem how clinically diagnostic cells represented on smears because this is the major cause of false negative results. Liquid-based sampling using whole specimens may solve this prpblem. We confirmed the accuracy of thin-layer preparation from liquid-based sampling.<BR><B><I>Method</I>:</B> Immediately after making a conventional smear, the device was rinsed in preservative fluid and dispersed cells pushed through the filter (Cyringe). Clinically diagnosable cells were concentrated by a density gradient. After sedimentation, samples redispersed in saline were placed on an automated thin layering machine (AutoCyte PREP). Conventional and thin-layer smears were compared for sensitivity and specificity.<BR><B><I>Results</I>:</B> Cell debris and degenerative inflammatory cells were markedly reduced and cells stained well. Microorganisms remained. Nine cases of low-grade squamous intraepithelial lesions were detected from 242 cases using both methods. Cancer cells and dysplastic cells were more concentrated in squamous cell carcinomas.<BR><B><I>Conclusion</I>:</B> Thin-layer preparation improved clinical diagnosis. The swift scanning of thin-layer smears on 13 mm circles ensure sensitivity and reliability.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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