A case of neuroendocrine carcinoma of the prostate.
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概要
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<B><I>Background</I>:</B> Neuroendocrine carcinoma (NEC) of the prostate is rate, with the few cases known found by urinary cytology.<BR><B><I>Case</I>:</B> A 78-year-old man with pollakiuria was found to have well differentiated adenocarcinoma of the prostate by needle biopsy. Urinary cytology at that time suggested probable adenocarcinoma cells. After 3 years and 5 months, the patient underwent (TUR) due to dysuria. Histologically, tumor cells revealed NEC features with an adenocarcinoma component. Postoperative urinary cytology exhibited exclusively small cells with naked nuclei, scattered and occasionally forming small clusters arranged in single file. Tumor cells featured a high N/C ratio, hyperchromatic nuclei, and scanty cytoplasm. Immunohistochemically, NEC tumor cells were positive for neuron-specific enolase, synaptophysin, and chromogranin A. Adenocarcinoma cells were positive for prostatic-specific antigen and prostatic acid phosphatase.<BR><B><I>Conclusion</I>:</B> In the daily screening of urine cytology in prostatic adenocarcinoma follow-up, it is important to remember that even typical adenocarcinoma may undergo NEC differention.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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