A case of primary leptomeningeal malignant melanoma diagnosed by cerebrospinal fluid cytology.
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概要
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<B><I>Background</I>:</B> We report a case of primary leptomeningeal malignant melanoma whose diagnosis is verified by cytological examination of the cerebrospinal fluid (CSF).<BR><B><I>Case</I>:</B> A 20-year-old man reported shoulder discomfort, headache, nausea, and vomiting lasting about 1 year. Cytological study of the CSF disclosed scattered atypical cells with a high nuclear-cytoplasmic ratio and prominent nucleoli. Although a provisional diagnosis of malignant lymphoma was made based on cytological features, the immunocytochemical study did not support this. Second cytological examination of the CSF showed scattered, loosely clustered atypical cells in which cytoplasmic brown pigments were found after extensive observation. These pigments were positively stained with DOPA reaction and Fontana Masson stain. An immunohistochemical study showed positive reactivity of atypical cells with S-100 protein and HMB 45 antibodies.<BR><B><I>Conclusion</I>:</B> A careful search of abnormal cytoplasmic pigments in atypical cells is therefore essential in diagnosing malignant melanoma in CSF cytology.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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