Significance of nuclear DNA content analysis in advanced lung cancer using transbronchial biopsy samples.
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Nuclear DNA content analyses were performed in 48 cases of advanced lung cancer using transbronchial biopsy samples. More than one hundred cells were suitable for analysis in 43 cases. Mean nuclear DNA content (MNDC) was 3.36c±0.77 and incidence of aneuploid stem cell lines (IASCL) was 72%(31/43) in all cases. There were no differences in MNDC or IASCL among histologic types. The MNDC of N 3 cases was significantly larger than that of N 0-2 cases (p <0.01), and the MNDC of M 1 was significantly larger than that of M 0 (p <0.05). The IASCL of N 3 cases was significantly higher than that of N 0-2 (p <0.05), and the IASCL of M 1 was significantly higher than that of M 0 (p <0.02). These results were obtained from analyses of non small cell lung cancers.<BR>The cases with larger MNDC (4.00C≥MNDC) had significantly shorter survival than the those with smaller MNDC (4.00 C < MNDC)(p < 0.01) in both total and non small cell lung cancer cases. These results indicate that nuclear DNA content analysis using transbronchial biopsy samples, might be useful for the prediction of tumor progression, especially metastasis, and prognosis in advanced lung cancer.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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