A case report of malignant struma ovarii.
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A 26-year-old nulliparous woman with amenorrhea but otherwise no particular complaint was found to be in the seventh week of pregnancy and to have left ovarian tumor by ultrasonography. Ovariectomy revealed an 8-cm dermoid cyst with hair, fat and a yellowish solid lesion measuring 5 cm in greatest diameter. The imprint smears showed a thyroid follicle pattern: cells with round nuclei around colloid substance with anisocytosis and stratification. Some of them had nuclear grooving and pseudo-inclusion, suggesting papillary carcinoma.<BR>Histologically, the tumor had mature teratoid elements: skin with appendage glands, brain and cartilage. The solid lesion presented as thyroid tissue with mild nuclear anaplasia, capsular and vascular invasions compatible with follicular carcinoma but without papillary change. Grimelius and Fontana-Masson staining were negative. Immunohistochemical studies showed expression of thyroglobulin but not calcitonin. Ultrastructurally, the nuclear cleavage and pseudoinclusion were not remarkable ; however, they were unlikely for a benign lesion. Flow cytometric DNA measurement showed a poly ploid pattern, suggesting malignancy.<BR>The final diagnosis, made with the support of ultrastructural, immunohistochemical and DNA analysis studies, was papillary carcinoma, follicular variant, of struma ovarii.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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