Quantitative analysis of nuclear distribution pattern in endometrial proliferative lesions.
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概要
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A new quantitative method of analyzing the distribution pattern (DP) of nuclei within cell clusters was described and applied to the differential diagnosis of hyperplastic and malignant lesions in endometrial cytology.The DP index can be defined as r√n<SUB>0</SUB>, where r is the mean distance between the closest nuclei and n<SUB>0</SUB> represents nuclear density.The mean of estimated DP indices was 0.826±0.029 in 22 normal cases, 0.735±0.019 in 16 cases of adenomatous and atypical hyperplasia, and 0.641±0.046 in 19 cases of well-differentiated adenocarcinoma.The DP indices of these conditions were significantly different (p<0.01).This indicates that the nuclear DP index can be helpful in differentiating between benign and malignant endometrial lesions.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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