Aspiration cytology of cystic glucagonoma of the pancreas. A case report.:A case report
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A 76-year-old female was admitted to our hospital, complaining of epigastralgia. Gall stones and a cystic tumor of the pancreatic body were found on further examination. Aspiration cytology of the pancreatic cyst was performed during surgery. A moderate number of tumor cells loosely connecting with each other were found in the smears. Both tumor cells and their nuclei were round and of almost the same size. The nuclei had a smooth margin, and showed a fine reticular chromatin pattern. The cytoplasm of the tumor cells was faintly stained and had a blurred margin.<BR>An enucleated pancreatic tumor measured 2.5×2.5cm in two diameters and had a cystic cavity containing bloody fluid and having a thin and yellowish friable wall. It was diagnosed as a non-functional glucagonoma, because almost all of the tumor cells gave a positive reaction with glucagon on immunohistochemical examination, but this patient did not present with either glucagonemia or symptoms.<BR>Almost all cystic pancreatic tumors originate in the pancreatic duct and contain features of mucinous and serous types, but a small number of cystic islet cell tumors have been reported. Cells of islet cell tumors in cytologic smears are able to be differentiated from those of the mucinous type tumors, which show the presence of mucin in the cytoplasm, and from the serous type, which contain cytoplasmic glycogen granules, and tumor cells of both types appear in the smears and frequently form tightly connected cell clusters. These findings and those in the present case are thought to be of great value in the differential diagnosis of cystic tumors of the pancreas.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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