Studies on the effect of danazol by hormonal cytology.
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The 81 patients with endometriosis were treated with danazol. Their endocrine status induced by danazol were investigated by means of hormonal cytology of vaginal smear. In the preliminary study, it was concluded that the intermediate cells could be classified into large and small ones. Our modified maturation index of the squamous epithlium was expressed as a percental relationship among parabasal cells, small intermediate cells, large intermediate cells and superficial cells.<BR>4 types vaginal cytology was defined. Maturation index of superficial cell type (S-type) contained superficial cells in more than 10% of the cells. Parabasal cell type (P-type) contained parabasal cells in more than 10% of the cells. The other type was defined as the intermediate cell type. Intermediate cell type was divided into 2 types such as type I consisting of large intermediate cells and type II consisting of small intermediate cells in more than 71% of the intermediate cells. Vaginal cytology obtained from the patients treated with danazol showed that S-type was observed in 15% of the smears, P-type in 16%, type I in 36% and type II in 33%.<BR>Appearance rates of S-type and type I were higher than type II and P-type till 4 months since beginning of danazol administration. Type II and P-type were frequently observed after 7 months of its treatment. Serum E2 values obtained that there was no significant change among E2 values of type I, type II and P-type. This study suggested that this method was useful to evaluate the endocrine status of the patient treated with danazol.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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