A case of Leydig cell tumor of the testis in a patient with Klinefelter's syndrome.
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A Leydig cell tumor arising in the testis of a 35-year-old male with Klinefelter's syndrome is reported. The patient, whose karyotype was 46, XX/47, XXY complained of infertility. His testes were bilaterally small, and no germinal cells were found in the atrophic seminiferous tubules, which were lined only with Sertoli cells. A yellowish brown Leydig cell tumor, measuring 0.9×0.9×0.6cm in size, was located in the upper portion of the left testis. The imprint smear obtained from a cut surface of the tumor showed that the tumor cell had a round to oval, eccentric nucleus with one or two prominent nucleoli, and abundant, pale, cyanophilic cytoplasm with a large number of vacuoles, which, on the basis of electron microscopic study, were very likely derived from well-developed smooth endoplasmic reticulum. Some tumor cells had abundant lipofuscin. Reinke's crystals were found in and out of the tumor cells. There were neither areas of tumor cell necrosis nor marked mitotic activity suggestive of malignancy in the imprint smear.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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