Enzyme and immunocytochemical study of osteosarcoma cells in pleural effusion. A case report with a reference on differential diagnosis of bone tumors.:A case report with a reference on differential diagnosis of bone tumors
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In order to differentiate whether a malignant bone tumor was osteosarcoma or a malignant giant cell tumor, enzyme cytochemistry and immunocytochemistry for alkaline phosphatase and acid phosphatase were performed on cell materials.<BR>Tumor cells obtained by pleural aspiration showed mostly a spindle-shape. Small numbers of osteoclastelike cells or pleomorphic multinuclear giant cells were also found. Although a diagnosis of malignant bone tumor was possible, it was difficult to differentiate osteosarcoma from malignant giant cell tumor by usual cytological examinations. Using enzyme and immunocytochemical procedures, alkaline phosphatase activity was revealed along the plasma membrane or in the cytoplasma of the tumor cells, while acid phosphatase activity was not found. These results were coincident in the histochemical results of the tissue materials and a diagnosis of osteosarcoma was confirmed.<BR>Enzyme and immunocytochemistry of alkaline phosphatase and acid phosphatase are effective in differentiating osteosarcoma from malignant giant cell tumor in the field of cytological diagnosis as they are in histochemical diagnosis.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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