Endometrial Smear in the study of Infertility

概要

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Endometrial glycogen and nidation have an importantrelationship. Nidation is known to be quiteimpossible, if the glycogen level of endometrial cellis low, even in the presence of a histologicallynormal endometrium. Glycogen can be demonstrated by the periodic acidschiff reagent (PAS) staining technique. I have examined the amount of glycogen in theendometrial cells by staining endometrial aspirationsmear with this PAS reagent. Functional infertility patients have a normal infertilitywork up with a histologically normal lookingsecretory endometrium. However, by the PASstaining of the endometrial aspiration smears, Ihave demonstrated, a lowering of glycogen, contentat the cellular level in these women. In functional infertility group of 441 cases. Negativeglycogen was present in the early secretoryphase in 32.7% of these cases compared to only11.9% in the controls. Negative glycogen was present in the late secretoryphase in 41.6% of these cases compared to10.8% in the controls. In the 164 cases of anovalatory infertility glycogenwas negative in 131 cases (79.8%). This lowering of glycogen is a key point in functionalinfertility making this PAS staining techniquean important test. It can be carried out routinelyand repeatedly with great simplicity.
特定非営利活動法人日本臨床細胞学会の論文