Intraepidermal Mass of M. leprae in a Case of Seborrheic Keratosis due to Hansen's Disease (LLs)
スポンサーリンク
概要
- 論文の詳細を見る
A 67-year-old patienthashad exanthema in the lower right limb since 51 years ago(16 years old at onset), which underwentrepeated remission and recurrence. At present, he has bilateralsymmetrical widespread infiltrating exanthema and asymmetrical marked neuralhypertrophy, and has been diagnosed typical LLs (His father had the same disease). The exanthema recurred severalyears ago, and the patient is being treated for Hansen's disease. He had hada dark brown flat elevation with a roughsurf ace and the size of a small finger tip in his right abdominal skin for approximately 20 years. A biopsy was performed, and the specimenwas fixed in 10% formalin and paraffin sections wereprepared for histopathologic examination. A part of the specimen was processed f orscanning electron microscopic examination. Seborrheic keratosis was diagnosed by H & E staining. Acid-fast (FITE) staining, immunohistochemical staining (keratin, S-100 protein, anti-PGL antibody and antiBCG antibody) and scanning electron micro scopy revealed the presence of bacteria (M. leprae) in the dermal foam cells, the matri with a banded structure and the squamous epithelial cells which normally lack phagocytosis function. Compared to the basal cells of normal epidermis, the basal cells located adjacent to the dermis affected with seborrheic keratosisshowed increased proliferatin and more marked characteristics of a germinative cell. The degree of differentiation of the basal cells appeared regressed, and they probably possessed augmented hagocytic activity. The phagocytosed bacteria were probably carried by the epidermal cell cycle toward the surface layer. However, bacteria could not be found in the stratum corneum, probably due to an associationwith the lysosome.
- 日本ハンセン病学会の論文
日本ハンセン病学会 | 論文
- NOによる細胞内感染防御の新しい展開
- ハンセン病多発国における神経障害の頻度と治療効果についてミャンマーにおける共同研究の結果から
- ハンセン病には不確定なことが多い
- ハンセン病とPCR
- ミャンマー、セガイン州カリイにおけるハンセン病のコントロール・プログラム