Evaluation of Circulating Immune Complexes in Leprosy in Relation to Clinical Activity, Antileprosy Agents, Bacterial Indexes and Anti-DNA Antibodies
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概要
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Circulating immune complexes (CIC) were detected by Clq solid phase assay in 120 Japanese patients with leprosy and evaluated in relation to clinical activity, antileprosy agents, bacterial indexes and anti DNA antibodies.Following results were obtained ;1) The mean level of CIC in lepromatous, borderline and tuberculoid leprosy was high in comparison with those of control (Fig. 1.).2) In lepromatous leprosy, the positivity and mean level of CIC had the tendency to increase with activity of clinical stage. Statistical analysis revealed the significant difference between p & r1 and r3 & q groups (0.02<P<0.05) but no significant difference between p & r1 and r2 (Fig. 1).3) The incidence of CIC in B. I. (0) was 38.1% and that in B. I. (0.1-1.9) was 30.6%. The incidence in BI (2.0-2.9) and in BI (over 3.0) groups were relatively high, compared with BI (0) group. The mean CIC level of each BI varied almost parallel with the positivity of CIC. Maximum level of CIC was observed in BI (2.0-2.9), which was significantly different from BI (0) (p<0.01) (Fig. 2 and Table 1).4) The effects of antileprosy agents on CIC level in inactive patients with lepromatous leprosy were studied but there were no significant differences in CIC level (Fig. 3).5) Anti DNA antibodies, that is, anti single stranded DNA antibody, anti double-stranded DNA antibody and anti extractable nuclear antigen (ENA) antibody, were determined by radioimmunoassay in lepromatous and tuberculoid leprosy. A significant increase of anti ENA antibodies was found (Fig. 4).6) Correlation study between CIC and appearance of some anti DNA antibodies suggested anti DNA antibodies dib not play the significant role in the pathogenesis of leprosy (Table 2 and Table 3).
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