Effects of Lactulose Syrup on the Growth of Rats Fed at Different Levels of Dietary Protein.

概要

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The study was undertaken to determine the effects of lactulose syrup on the growth and intestinal microflora of rats at different levels of dietary protein. Male rats of the Wistar strain (at 6 weeks of age and weight 97 g) were fed two control diets (15 % casein and 35 % casein) containing no lactulose syrup and two experimental diets (15% casein and 35% casein) containing 19% lactulose syrup for 35 days. The following results were obtained : 1) The two lactulose groups showed a decrease in body weight gain and total feed intake for 35 days. 2) The growth ratio (body weight gain/initial body weight), the feed efficiency ratio and protein efficiency ratio were lower in the two lactulose groups than in each control group. 3) The weight of liver, kidney, small intestine and cecum with contents were increased in the two lactulose groups. The weight of retroperitoneal fat pads were decreased in the two lactulose groups, and this effect in rats fed the 35% casein diet was affected significantly. 4) In the fatty acid composition of retroperitoneal fat pads, linoleic acid was increased and palmitic acid decreased. 5) In the cecum, pH was decreased, and thiamin, riboflavin and <I>Bifidobacterium</I> were increased in the two lactulose groups. These effects in the 35 % casein diet group were demonstrated significantly.
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