Effect of Linoleate or Phospholipid on Urinary 17 KS and 17 OHCS Levels in Healthy Subject and Patients with Liver Disease

概要

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Urinary 17 KS and 17 OHCS levels were determined in normal subjects and patients with liver diseases after the administration of ethyl linoleate or phospholipid.<BR>After the administration of 9g ethyl linoleate per day, the average value of urinary 17KS was significantly increased, but no change of that of 17 OHCS was observed.<BR>In the normal subjects, given 1.0g or 1.5g of phospholipid per day, the levels of both of urinary 17 KS and 17 OHCS were significantly elevated.<BR>In the patients with acute hepatitis and liver cirrhosis, no remarkable changes were observed.<BR>From these results it was concluded that ethyl linoleate or phospholipid might play a important role in effecting on the function of the adrenal cortex.
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