Effect of Riboflavin Deficiency on Fatty Acid Oxidation of Rat Liver Mitochondria

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The effect of ribofiavin on the oxygen consumption of rat liver mitochondria with derivatives of palmitic acid was studied. It was found that under riboflavin deficiency decrease of oxidation of palmityl-CoA in the presence of L-carnitine was greater than that of palmityl-L-carnitine.<BR>When weanling rats were fed with riboflavin supplemented diet for 18 days and then with the deficient diet for following 31 days, the oxidative activity of palmityl-CoA with mitochondria in the presence of L-carnitine was reduced to the same level of that in rat fed with the deficient diet, whereas the reduction of that to palmityl-L-carnitine was less than that to palmityl-CoA in the presence of L-carnitine.<BR>The respiratory control ratio of the mitochondria was decreased by feeding the deficient diet for 4 weeks with both derivatives of palmitic acid. However, the rate of oxidative phosphorylation was not affected by the deficiency, using palmityl-L-carnitine as a substrate.
公益社団法人日本栄養・食糧学会の論文