Studies on the Metabolic Fate of 3H-TJN-101. (III): Absorption, Distribution and Excretion after Multiple Oral Administration to Rats.
スポンサーリンク
概要
- 論文の詳細を見る
The absorption, distribution, and excretion of <SUP>3</SUP>H-TJN-101 in male rats were studied following 21-day period of daily oral administration (4 mg/kg/day).<BR> 1. The radioactivity level in the blood at 1 and 24hr after oral administration rose as the number of doses increased, and the concentration at 1 and 24hr after the 21st dose was 1.6 and 3.9 times higher, respectively, than those after the first dose. The elimination half-life from 48hr after the 21st dose was 2.9 times longer than that after the first dose.<BR> 2. The concentrations of radioactivity in most tissues at 24hr after daily administration rose as the number of doses increased, but the elimination was slower in comparison with that after single dose.<BR> 3. Excretion of radioactivity in the urine and feces was almost constant after the 4th dose. One hundred and sixty-eight hr after the 21st dose, 12.9% and 80.6% of the radioactivity administered was excreted in the urine and feces, respectively.
- 日本薬物動態学会の論文
日本薬物動態学会 | 論文
- COMPETITIVE DISPLACEMENT OF SERUM PROTEIN BINDING TO REGULATE PHARMACOKINETICS OF A CEREBRAL BLOOD FLOW RADIOPHARMACEUTICAL
- Studies on the Metabolic Fate of Felodipine. (IV). Identification of New Metabolites of Felodipine in Rat.
- Metabolic Fate of Pergolide Mesylate. (2): Absorption, Distribution, Excretion of 14C-Pergolide Mesylate in Rats after Repeated Administration.
- Studies on the Metabolic Fate of 3H-TJN-101. (III): Absorption, Distribution and Excretion after Multiple Oral Administration to Rats.
- Studies on the Pharmacokinetics of Perindopril Erbumine in Rats. (1): Plasma Level Profile, Distribution, Metabolism and Excretion after Single Oral Administration.