Studies on the Metabolic Fate of Felodipine. (IV). Identification of New Metabolites of Felodipine in Rat.
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概要
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Two novel metabolites of felodipine were isolated from rat bile or in an <I>in vitro</I> system using rat liver preparations. Their chemical structures were identified by comparative analysis with authentic samples.<BR> Both metabolites were formed by ester hydrolysis of felodipine. One was a 3-carboxyl derivative and the other a 5-carboxyl derivative ; both were identified as having dihydropyridine structures and were shown to be major metabolites in rat plasma.
- 日本薬物動態学会の論文
日本薬物動態学会 | 論文
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