Studies on the metabolic fate of Benazepril hydrochloride in rats III: Investigation of placental transfer and tranfer into milk.
スポンサーリンク
概要
- 論文の詳細を見る
The distribution of radioactivity in the fetus and its transfer into milk were examined after single oral administration of 3mg/kg of <SUP>14</SUP>C-CGS 14824 A to pregnant or lactating rats.<BR> 1. On the whole body autoradiograms on day 12 of gestation, the radioactivity in the fetus was very low at every time point.<BR> 2. The whole body autoradiograms taken on day 18 of gestation, revealed a very low radioactivity in the fetus. Radioactivity in the ovary, placenta and uterus was higher than that in plasma of the dam at 6hr. Only low levels of radioactivity were observed in the fetal lung and fetal liver.<BR> 3. After oral administration of <SUP>14</SUP>C-CGS 14824 A to lactating rats, the radioactivity in the milk was not observed 20min after the dosing. The radioactivity remained constant between lhr and 24hr and Cmax was observed at 4 hr. The radioactivity in the milk was less than 39% of the plasma level at every time point. At 48hr, the radioactivity was no longer observed in the milk.
- 日本薬物動態学会の論文
日本薬物動態学会 | 論文
- COMPETITIVE DISPLACEMENT OF SERUM PROTEIN BINDING TO REGULATE PHARMACOKINETICS OF A CEREBRAL BLOOD FLOW RADIOPHARMACEUTICAL
- Studies on the Metabolic Fate of Felodipine. (IV). Identification of New Metabolites of Felodipine in Rat.
- Metabolic Fate of Pergolide Mesylate. (2): Absorption, Distribution, Excretion of 14C-Pergolide Mesylate in Rats after Repeated Administration.
- Studies on the Metabolic Fate of 3H-TJN-101. (III): Absorption, Distribution and Excretion after Multiple Oral Administration to Rats.
- Studies on the Pharmacokinetics of Perindopril Erbumine in Rats. (1): Plasma Level Profile, Distribution, Metabolism and Excretion after Single Oral Administration.