Bioavailability of slow-release metoprolol tartrate 120mg tablet in comparison with conventional metoprolol tartrate 40mg tablets in healthy volunteers.
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A total dose of 120 mg metoprolol tartrate was given to 12 healthy male volunteers as a slow-release metoprolol 120 mg tablet or conventional metoprolol 40 mg tablets t.i.d.. The two formulations were administered according to a cross-over design. Slow-release 120 mg tablet was administered after breakfast while the conventional 40 mg tablets were administered after breakfast, lunch and dinner.<BR> The mean peak concentration (C<SUB>max</SUB>) values (±SE) of the slow-release 120 mg tablets and conventional 40 mg tablets were 135.5±23. 2ng/m<I>l</I> and 105.8 ±15. 5ng/m<I>l</I>, respectively. The mean area under the concentration time curve(AUC<SUB>0-24</SUB>) values (±SE) of the slow-release 120mg tablets and conventional 40 mg tablets were 1251.8±270.1 and 1141.3±224.3ng·hr/m<I>l</I>, respectively. AUC<SUB>0-24</SUB> values of individual volunteers in the slow-release 120 mg u, i, d conventional 40 mg tablets t. i. d. group correlated very well with each other(r=0.960, P<0.01). <BR>Therefore, the bioavailability of slow-release 120 tablet u.i.d. was equivalent to that of conventional 40 mg tablets t.i.d..
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