Studies on the Metabolic Fate of Mometasone furoate (MF). (1). Percutaneous Absorption, Distribution, Excretion after Topical Application to Rats and Rabbits.
スポンサーリンク
概要
- 論文の詳細を見る
The absorption and excretion of <SUP>14</SUP>C-MF in rats and rabbits were studied following topical application of 0.1% dermal formulations mostly as a form of ointment.<BR>1. When the ointment was applied to the intact skin, radioactivity was not detected in plasma of both rats and rabbits. Less than lOng equiv./m<I>l</I> of radioactivity was detected after application to the stripped skin in both animal species, and it disappeared 24 or 48hr after application.<BR>2. The absorption of radioactivity from the ointment in rats, estimated as the sum of urinary and fecal excretion, was 5 ?? 10% of the applied dose in intact skin and 30 ?? 50% in stripped skin. In rabbits, it was lower than those of rats.<BR>3. Radioactivity was predominantly excreted in feces than in urine in both animal species, and this difference was more prominent in rats than in rabbits.<BR>4. Female rats showed slightly higher absorption ratio as compared to male rats. It probably was due to the difference of skin thickness, less thinner skin was observed in females than in males.<BR>5. When <SUP>14</SUP>C-MF was applied as a cream or lotion to intact skin of rats, almost same results as those of ointment were obtained.
- 日本薬物動態学会の論文
日本薬物動態学会 | 論文
- COMPETITIVE DISPLACEMENT OF SERUM PROTEIN BINDING TO REGULATE PHARMACOKINETICS OF A CEREBRAL BLOOD FLOW RADIOPHARMACEUTICAL
- Studies on the Metabolic Fate of Felodipine. (IV). Identification of New Metabolites of Felodipine in Rat.
- Metabolic Fate of Pergolide Mesylate. (2): Absorption, Distribution, Excretion of 14C-Pergolide Mesylate in Rats after Repeated Administration.
- Studies on the Metabolic Fate of 3H-TJN-101. (III): Absorption, Distribution and Excretion after Multiple Oral Administration to Rats.
- Studies on the Pharmacokinetics of Perindopril Erbumine in Rats. (1): Plasma Level Profile, Distribution, Metabolism and Excretion after Single Oral Administration.