Steroidal aromatase inhibitors: Specific inhibitors of estrogen biosynthesis.
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概要
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Aromatase is the cyt. P-450 enzyme that mediates the biosynthesis of estrogens from androgen precursors. A large number of steroids have been evaluated as potential aromatase inhibitors, and they are classified into three groups, competitive inhibitor, affinity label and suicide substrate, according to their inhibition manner. Specific inhibitors of this enzyme have application as research tools for investigating aromatization mechanism, and are of pharmacological interest because of their possible use for treatment of estrogen-dependent deseases such as breast cancer and benign prostatic hyperplasia. Biochemical aspects of the activity of known steroidal aromatase inhibitors, their structure-activity relationships and their use for clinical treatment are discussed.
- 日本薬物動態学会の論文
日本薬物動態学会 | 論文
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