Studies on the gastrointestinal absorption of ethyl eicosapentaenoate(EPA-E) in rats.
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概要
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The absorption site and route of ethyl-eicosapentaenoate (EPA-E), the effect of bile, and particle size and purity of EPA-E on the absorption and identity on the absorption between EPA-E and sodium eicosapentaenoate (EPANa) were investigated after oral administration of <SUP>14</SUP>C-EPA-E or <SUP>14</SUP>C-EPANa in rats and the following results were obtained.<BR> 1. Radioactivity was rapidly absorbed from the small intestine and only 4.6% of the administered radioactivity was recovered from the intestine and intestinal contents at 24 hr after dosing.<BR> 2. Radioactivity was mainly absorbed through a lymphatic route after oral administration of <SUP>14</SUP>C-EPA-E.<BR> 3. The absorption of <SUP>14</SUP>C-EPA-E was promoted by a supply with bile.<BR> 4. It was presumed that the smaller particle size of EPA-E, showed the greater the absorption.<BR> 5. It was thought that there is no significant difference in the gastrointestinal absorption between EPA-E and EPANa.<BR> 6. The absorption of EPA-E from the gastrointestinal tract was not influenced by purity of EPA-E.
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