Incidentally Discovered Adrenocortical Adenomas Are Not Fully Nonfunctioning: Immunohistochemical and Dispersed Adrenocortical Cell Study.:Immunohistochemical and Dispersed Adrenocortical Cell Study
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the precise function of incidentally discovered adrenocortical adenoma, immunohistochemical and dispersed adrenal cell studies were performed. We have recently seen five patients with so-called nonfunctioning adrenocortical adenoma. Diurnal variation in plasma cortisol and suppression of plasma cortisol and urine 17-hydroxycorticosteroids in response to dexamethasone administration revealed adrenocortical function within normal limits in all cases, and no signs or symptoms of adrenal steroid hormone excess were evident. Since a high uptake of iodomethyl-norcholesterol was recognized in each adrenal mass, it was supposed that these adrenal tumors produced steroid hormone to a certain extent, and each patient received unilateral adrenalectomy. P450c17, a key enzyme involved in cortisol production, was expressed in the tumor region in all cases in an immunohistochemical study. Upon in vitro steroidogenesis with dispersed adrenal cells in two cases, all steroid hormones measured except for aldosterone (progesterone, 17α-hydroxyprogesterone, pregnenolone, 17α-hydroxypregnenolone, 11-deoxycortisol, cortisol, 11-deoxycorticosterone, corticosterone, 18-hydroxydeoxycorticosterone, dehydroepiandrosterone and androstenedione) were produced in a culture medium. The results indicated that these tumors possessed the capacity for cortisol production, which was in agreement with the results of an iodomethyl-norcholesterol scintigraphy. All patients with mild hypertension or diabetes mellitus had no signs or symptoms of steroid hormone excess, but they could potentially develop a steroid excess syndrome such as Cushing's syndrome in the future.
- 一般社団法人 日本内分泌学会の論文
一般社団法人 日本内分泌学会 | 論文
- 性ホルモンと生体反応
- A Hexapeptide Angiotensin Antagonist, [Des-(Asp1, Arg2), Ile8]-Angiotensin II
- 甲状腺ホルモンの吸収に関する研究
- DISC ELECTROPHORETIC ANALYSIS OF GROWTH HORMONE AND PROLACTIN IN THE ANTERIOR PITUITARY OF MOUSE
- 機能性甲状腺結節 (Autonomous Functioning Thyroid Nodule) 及び周辺組織におけるヨード代謝