Effect of CL 316, 243, a Novel.BETA.3-Adrenoceptor Agonist, on Insulin Secretion in Perfused Mouse Pancreas.
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In order to clarify the insulin-release mechanism of β<SUB>3</SUB>-adrenoceptor agonist, we examined the effect of CL 316, 243, a highly specific β<SUB>3</SUB>-adrenoceptor agonist having a relative potency of β<SUB>1</SUB>:β<SUB>2</SUB>:β<SUB>3</SUB> = 0: 1: 100, 000, on insulin secretion in perfused mouse pancreas. The application of 0.2 mM and 0.5 mM CL 316, 243 produced significant insulin secretion from within 1 min, which lasted until 2 min after its withdrawal. DL-propranolol and ICI 118551 at 0.2 mM partially inhibited the insulin secretion induced by. the 0.2 mM CL 316, 243, but 0.2 mM metoprolol had no effect on the insulin release produced by 0.2 mM CL 316, 243. We conclude that β<SUB>3</SUB>-adrenoceptor agonist stimulates insulin secretion via β<SUB>3</SUB>-action in the perfused mouse pancreas.
- 一般社団法人 日本内分泌学会の論文
一般社団法人 日本内分泌学会 | 論文
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