Circulating Activated T Lymphocyte Subsets in Patients with Silent Thyroiditis.
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概要
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In order to investigate the immunological aspects of silent thyroiditis, T lymphocyte subsets were analyzed by two-color flow cytometry in 10 patients with silent thyroiditis in the thyrotoxic phase, 12 patients with silent thyroiditis in the recovery phase, and 11 healthy volunteers as a control. The percentages of CD3<SUP>+</SUP> CD4<SUP>+</SUP>, and CD8<SUP>+</SUP> cells were similar in all three groups. In contrast, activated matured T (HLA-DR<SUP>+</SUP>CD3<SUP>+</SUP>), activated helper/inducer T (HLA-DR<SUP>+</SUP>CD4<SUP>+</SUP>) and activated suppressor/cytotoxic T (HLA-DR<SUP>+</SUP>CD8<SUP>+</SUP>) cells were more numerous in both the thyrotoxic and the recovery phases of patients with silent thyroiditis when compared with healthy controls. In a serial study of 6 patients with silent thyroiditis, the percentage of activated helper/inducer T (HLA-DR<SUP>+</SUP>CD4<SUP>+</SUP>) cells was higher in the thyrotoxic phase than in the recovery phase. These data indicate that the activation of T cells, especially of helper/inducer T cells, might be important for the induction of silent thyroiditis.
- 一般社団法人 日本内分泌学会の論文
一般社団法人 日本内分泌学会 | 論文
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