Influence of arotinolol hydrochloride on heart rate spectrum in hypertensive subjects.
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Influence of arotinolol hydrochloride and atenolol on the balance between the sympathetic and parasympathetic nervous systems was evaluated in 8 hypertensive subjects by spectral analysis of heart rate (HR) and systemic blood pressure (BP). Before and after administration of either arotinolol (n=7) or atenolol (n=7) for 2 weeks, BP was continuously and non-invasively monitored by a finger-cuff manometry (Finapres) . A time series of instantaneous HR was constructed from the BP signal. A time series of mean BP was also constructed. Spectral analysis was performed by the use of an autoregressive algorithm on these time series (∼180 sec). Each spectrum was subdivided into low-(0.05-0.15 Hz, LF) and high-frequency (0.15-0.4 Hz, HF) components, and each component was divided by the sum of the two for normalization. As a measure of the balance between the sympathetic and parasympathetic nervous systems, the ratio of LF to HF (LF/HF) was evaluated. Arotinolol increased fractional HF in the HR spectrum from 0.45±0.12 to 0.73±0.08 (p<0.01) and decreased fractional LF from 0.55±0.12 to 0.27±0.08 (p<0.01); consequently, it decreased LF/HF from 1.4±0.5 to 0.4±0.2 (p<0.01). Atenolol had similar effects on these parameters. Neither of these β-adrenergic blockades produced a discernible decrease in LF/HF in the BP spectrum. In conclusion, these β -adrenergic blockades decreased LF/HF in the HR spectrum in hypertensive subjects, which suggests that they improved the balance between the sympathetic and parasympathetic nervous systems.
- 社団法人 日本循環器学会の論文
社団法人 日本循環器学会 | 論文
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