ANTIARRHYTHMIC AND MYOCARDIAL METABOLIC EFFEDTS OF VERAPAMIL DURING CORONARY ARTERY REPERFUSION
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The accumulation of metabolic intermediates subsequent to impaired β-oxidation of free fatty acids has been suggested to be a cause of cellular damage and ventricular arrhythmias in the ischemic heart. The effects of verapamil on ventricular arrhythmias and free fatty acids metabolism during coronary artery reperfusion in experimental dogs were evaluated over a period of 40 minutes and followed by reperfusion for 15 minutes. One tenth mg/kg/min of verapamil was administered for 5 minutes before occlusion and followed by an infusion of 0.01 mg/kg/min to the end of the experiment. Myocardial samples were obtained from both the non-ischemic and ischemic areas after coronary artery reperfusion and then ATP, free carnitine, long chain acyl carnitine and long chain acyl CoA were measured. In the control group, 3 dogs (27%) had ventricular fibrillation and 2 dogs (18%) had ventricular tachycardia during coronary occlusion. In addition, 2 dogs (25%) developed ventricular fibrillation after reperfusion. On the other hand, all 6 dogs treated with verapamil had neither ventricular fibrillation nor tachycardia during both coronary artery occlusion and reperfusion. ATP and free carnitine levels in the ischemic area were significantly higher in the verapamil group than in the control group (ATP: p<0.01, free carnitine: p<0.05). while long chain acy1 carnitine levels in the ischemic area were significantly lower in the verapamil group then in the control group(p<0.01)However, there was no significant change in long chain acyl CoA levels between the control and verapamil groups. This study shows that verapamil protects against ventricular arrhythmias and has beneficial effects on the metabolization of free fatty acids. In conclusion, it is suggested that one of the antiarrhythmic mechanisms of verapamil in ventricular tachyarrhythmias may be due to the prevention of the accumulation of metabolic intermediates of free fatty acids.rights:社団法人日本循環器学会rights:本文データは学協会の許諾に基づきJournal Archiveから複製したものである
- 社団法人 日本循環器学会の論文
- 1984-00-00
社団法人 日本循環器学会 | 論文
- ANTIARRHYTHMIC AND MYOCARDIAL METABOLIC EFFEDTS OF VERAPAMIL DURING CORONARY ARTERY REPERFUSION
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