EFFECTS OF PROPRANOLOL AND DILTIAZEM ON THE RATE OF HIGH-ENERGY PHOSPHATE METABOLISM IN REPERFUSED RAT HEARTS
スポンサーリンク
概要
- 論文の詳細を見る
The relationships between pressure rate product (PRP) and flux (PCr→ATP) or flux (Pi→ATP) were studied in isolated perfused rat hearts by the saturation transfer method using 31P-NMR. The effects of propranolol and diltiazem on phosphate metabolism were also studied. After a 40 min preischemic period, the hearts were subjected to a 15 min period of ischemia, followed by 60 min of reperfusion. Propranolol (0.4-1.2μM) or diltiazem (3.0-6.0μM) was infused for 30 min before ischemia and reinfused after reperfusion for 60 min. The flux (PCr→ATP)/PRP ratio at reperfusion did not differ from that at preischemia. This value was also not affected by propranolol or diltiazem treatment. However, the flux (Pi→ATP)/PRP ratio at reperfusion was significantly less than that at preischemia. Moreover, this value was significantly improved by propranolol or diltiazem treatment. This study demonstrates that 1) flux (PCr→ATP) has a good correlation with cardiac performance, 2) stunned myocardium needs less ATP turnover for survival of its depressed contractile activity, and 3) flux (Pi→ATP) can limit recovery of postischemic performance. Protective effects of propranolol and diltiazem are exerted on the flux (Pi-ATP), i.e. ATP derived from glycolytic flux, in the reperfused heart.rights:社団法人日本循環器学会rights:本文データは学協会の許諾に基づきJournal Archiveから複製したものである
- 社団法人 日本循環器学会の論文
- 1992-00-00
社団法人 日本循環器学会 | 論文
- ANTIARRHYTHMIC AND MYOCARDIAL METABOLIC EFFEDTS OF VERAPAMIL DURING CORONARY ARTERY REPERFUSION
- EFFECTS OF PROPRANOLOL AND DILTIAZEM ON THE RATE OF HIGH-ENERGY PHOSPHATE METABOLISM IN REPERFUSED RAT HEARTS
- SIMULTANEOUS DUAL MYOCARDIAL IMAGING WITH IODINE-123-β-METHYL IODOPHENYL-PENTADECANOIC ACID (BMIPP) AND THALLIUM-201 IN PATIENTS WITH CORONARY HEART DISEASE
- EFFECTS OF L-CARNITINE ON VENTRICULAR ARRHYTHMIAS IN DOGS WITH ACUTE MYOCARDIAL ISCHEMIA AND A SUPPLEMENT OF EXCESS FREE FATTY ACIDS
- EFFECTS OF L-CARNITINE ON TISSUE LEVELS OF ACYL CARNITINE, ACYL COENZYME A AND HIGH ENERGY PHOSPHATE IN ISCHEMIC DOG HEARTS