A study on the cardiodepressant action of a .BETA.-blocking agent carteolol in heart-lung preparation of the dog.

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Direct cardiodepressant activities of three β-blockers, carteolol, pindolol and propranolol, were estimated using heart-lung preparation of the dog. β-blocking doses of these drugs to inhibit the positive chronotropic effect of isoproterenol by 50% were 2.2 μg for carteolol, 4.0 μg for pindolol and 21 μg for propranolol. Cardiac performance of the preparation was not influenced by up to 1 mg of these three β-blockers. After 10 mg of these drugs, the cardiac function curves were shifted rightward and downward indicating the heart failure. It was doubtful however, that this result indicated the cardiodepressant action of β-blockers, for the preparation showed spontaneous deterioration without β-blocker treatment. The influences of these β-blockers on the compromized heart-lung preparations showed essentially similar results. In conclusion, direct cardiodepressant activity of the β-blocking doses. The implication of the results in clinical use of β-blockers, especially in relation to heart failure, was discussed.
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