Augmentation of Coronary Blood Flow in Acute Experimental Pulmonary Embolization

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It was initially suggested by Virchow(1856) that the cause of suddend death in acute pulmonary embolism was related to an acute decrease in coronary blood flow. In fact. myocardial ischemic change was frequently observed on electrocardiogram and autopsy after acute pulmonary embolism. For years, it was widely believed that acute pulmonary embolism might acctivate a vagal reflex which result in constriction of the coronary arteries. However. recent observations show that pulmonary embolization causes a coronary dilation or no Change. In order to clarify the effects of acute pulmonary embolism on the coronary circulation, the effects of recurrent miliary embolization with Lycopodium Spores on the right coronary blood flow (RCF) or left circumflex coronary bloodt flow (LCF) were studied in the open-chest anesthetized dogs, with special deference to partial pressure of oxygen in arterial blood (Pa0<SUB>2</SUB>) and coronary sinus blood (PcsO<SUB>2</SUB>). The effects of the partial occlusion of pulmonary trunk or pressure infusion into the separated left lower lobar artery on LCF were also studied.
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