Studies on the Thyroid in Spontaneously Hypertensive Rats : I. Thyroid Activity

概要

論文の詳細を見る
1. Elevated thyroid activity was observed in 40- to 60-day-old and 4- to 7-, 12- to 14- and 18-to 20-month-old SHR in at least one of the following four tests using radioactive iodine: the thyroidal 131I uptake, the rate of thyroidal 131I release, the conversion ratio and the thyroid hormone secretion rate. The thyroid hormone secretion rate was increased 37%, 18% and 27%, respectively in 40- to 60-day-old, and 4- to 6- and 12- to 14-month-old SHR. In 13- to 16-day-old SHR, however, neither the thyroidal 131I uptake nor the thyroid weight/body weight ratio differed from those in the control rats. 2. In the early (acute) and the advanced (chronic) stages of renal infarction and DCA hypertension, thyroid activity as assessed by the thyroidal 131I uptake did not differ from that in the sham-operated control rats, although increased thyroid weight/body weight ratios were observed in advanced stages. 3. Prolonged propylthiouracil (PTU) administration effectively reduced the blood pressure of both adult male SHR and control rats. The blood pressure of SHR was always higher than that of control rats during PTU administration. 4. On the basis of there results, the relation-ship between hypertension and thyroid activity, especially in SHR, is discussed.
社団法人日本循環器学会の論文