Effects of Protein Depletion on the Enzyme Activities of Liver and Muscle in Rats

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Experiments were carried out in attempt to determine whether the lability of enzyme protein in protein depletion is characteristic of enzyme itself or organ where enzyme exists in.<BR>In the first experiment, rats were killed on 1st, 2nd, 4th, 8th and 30th day after feeding a proteinfree diet and the activities of succinate dehydrogenase (E.C. 1. 33. 99. 1), aldolase (E.C. 4. 1. 2. 13) and phosphorylase (E.C. 2. 4. 11) were determined in liver and muscle. In liver and muscle the activity of succinate dehydrogenase and protein content decreased nearly exponentially until 8th day.<BR>In the second experiment, rats were fed a protein-free diet for 8 days. The activity of succinate dehydrogenase was decreased in liver but unchanged in muscle. Aldolase was not affected in liver and muscle. Phosphorylase was not affected in liver but decreased in muscle.<BR>These results suggest that the lability of enzyme protein will not be always related with protein metabolism of the tissue where the enzyme exists.
公益社団法人日本栄養・食糧学会の論文