Studies on the Physiological Action of Lysozyme (1):Effects of lysozyme administration on animals
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The physiological effect of lysozyme was examined. Lysozyme does not catalyze casein decomposition in vitro. On feeding rabbits and rats with the trial infant formula, containing 130mg Percent of lysozylme (Px), the following results were observed.<BR>1) Lysozyme content in human milk was determined as 3-10mg percent. Cow's milk contains only 0.03-0.17mg percent. Lysozyme content of cow's milk is about 1/100 of human milk.<BR>2) Lysozyme content in blood serum and feces, especially in feces, was increased when fed rabbits with the Px.<BR>3) Nitrogen distributions in feces of rabbits were determined by the use of Dowex-50 W ion exchange resin. Low molecular weight N-compounds in feces were increased by infant formula, Snow Brand Neomilk PF (PF), feeding compared with Oriental diet feeding. No significant difference in N-distribution in feces was observed between Px and PF feedings.<BR>4) On feeding rats with either Px or PF, the pH of feces was decreased and the count of <I>Lactobacillus bifidus</I> was increased. This tendency was especially remarkable with the Px feeding. Changing the feed to Oriental diet, pH of feces was again increased and the count of <I>Lactobacillus bifidus</I> was decreased.
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