Nedaplatin・5-FU併用療法により間質性肺炎を発症した舌, 肺重複癌の1例

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Platinum and fluorouracil (5-FU) chemotherapy is a common treatment for patients with oral cancer. Interstitial pneumonia has rarely been reported as a side effect of chemotherapy. We describe a case of interstitial pneumonia caused by nedaplatin and 5-FU treatment in a 63-year-old man with double cancer of the tongue and the lung. Two days after chemotherapy, blood tests revealed an elevation of C-reactive protein (CRP, 15.1 mg/dl). A chest X-ray film and computed tomography showed diffuse patchy shadows in both lung fields. Despite treatment with antibiotics, the CRP increased to 28.6 mg/dl, and the shadows became more pronounced by the fourth day. Drug-induced interstitial pneumonia was suspected. The patient was treated with steroids, and the shadows on his chest X-ray film improved. Twenty-seven days after chemotherapy, the patient received a partial tongue resection. We should pay much attention to the occurrence of the interstitial pneumonia caused by chemotherapy with platinum and fluorouracil, especially in patients with pulmonary diseases because they are at high risk. Early diagnosis and treatment are very important.
Japanese Society of Oral and Maxillofacial Surgeonsの論文