生体内での低出力超音波照射による生体活性純チタンの骨結合機能の促進効果

概要

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We have already reported the in vitro effect of the ultrasound wave stimulation for the hydroxyapatite-like crystalline formation on bioactive pure titanium surface, which indicate the clinical advantage to accelerate the bone-binding to bioactive material. In this study, animal experiment was performed in order to investigate the effect of ultrasound waving in vivo. Bioactive pure titanium was processed by the chemical treatment and the heat treatment, implanted to the rabbits femur, and undertaken the irradiation of ultrasound waving for planned time-periods. The titanium specimens taken from sacrificed rabbit was assessed by using Scanning Electron Microscope (SEM), histological observation and mechanical testing. As a result, the bone-bonding condition of titanium sample of the ultrasound waving radiation group was significantly excellent as compared with the non-ultrasound pulse group. These findings supported the result of previous in vitro study and suggested that the ultrasound waving had clinical potential to improve the osteointegration, bone-bonding ability for bioactive titanium implant.