Acquired von Willebrand Syndrome Associated with Hashimoto's Thyroiditis and Subcutaneous Mucosa-associated Lymphoid Tissue Lymphoma
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概要
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Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder with laboratory findings similar to those of congenital von Willebrand disease. We herein report a case of AVWS associated with Hashimoto's thyroiditis and subcutaneous mucosa-associated lymphoid tissue lymphoma. An IgG autoantibody against von Willebrand factor (VWF) was detected. The antibody bound to VWF but did not inhibit VWF activity. Rapid clearance of VWF seemed to be the cause of AVWS in the present case. VWF-containing concentrates stopped the bleeding. Even if such a complication is rare, for AVWS patients, prompt recognition of the underlying mechanism can save lives.
- 社団法人 日本内科学会の論文
著者
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KOYAMA Takatoshi
Graduate School of Health Sciences, Tokyo Medical and Dental University
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Shima Midori
Department Of Pediatrics Nara Medical University
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Shima Midori
Department of Pediatrics, Nara Medical University, Japan
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Fujimoto Kazumi
Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Japan
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