Association of Inflammatory Gene Polymorphisms and Conventional Risk Factors With Arterial Stiffness by Age
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概要
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Background: Inflammatory gene polymorphisms are potentially associated with atherosclerosis risk, but their age-related effects are unclear. To investigate the age-related effects of inflammatory gene polymorphisms on arterial stiffness, we conducted cross-sectional and 5-year follow-up studies using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness.<BR>Methods: We recruited 1850 adults aged 34 to 69 years from the Japanese general population. Inflammatory gene polymorphisms were selected from NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1, and TNF-α. Associations of CAVI with genetic and conventional risk factors were estimated by sex and age group (34–49, 50–59, and 60–69 years) using a general linear model. The association with 5-year change in CAVI was examined longitudinally.<BR>Results: Glucose intolerance was associated with high CAVI among women in all age groups, while hypertension was associated with high CAVI among participants in all age groups, except younger women. Mean CAVI for the CD14 CC genotype was lower than those for the TT and CT genotypes (P for trend = 0.005), while the CD14 polymorphism was associated with CAVI only among men aged 34 to 49 years (P = 0.006). No association of the other 6 polymorphisms with CAVI was observed. No association with 5-year change in CAVI was apparent.<BR>Conclusions: Inflammatory gene polymorphisms were not associated with arterial stiffness. To confirm these results, further large-scale prospective studies are warranted.
- 日本疫学会の論文
著者
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KUSANO Ken
JA Kagoshima Kouseiren Medical Health Care Center
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Takezaki Toshiro
Department Of International Island And Community Medicine Faculty Of Medicine Kagoshima University
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Niimura Hideshi
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Ogawa Shin
Department Of Applied Biochemistry Faculty Of Applied Biological Science Hiroshima University
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Nakamura Akihiko
Department Of Biomaterial Sciences Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Nakamura Akihiko
Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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Nakahata Noriko
Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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Kheradmand Motahare
Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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Kuwabara Kazuyo
Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
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Mantjoro Eva
Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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Shimatani Keiichi
Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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Nerome Yasuhito
Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
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Owaki Tetsuhiro
Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
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Niimura Hideshi
Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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Ogawa Shin
Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
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NAKAMURA Akihiko
Department of Applied Chemistry, Faculty of Engineering, Doshisha University
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