Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock

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概要

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• Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-photic signals to the hamster circadian clock.

• 公益社団法人 日本薬理学会の論文

著者

• FUJI Kazuyuki

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University

• Fukazawa Yuka

  Department Of Obstetrics And Gynecology Yokohama City University School Of Medicine

• Horikawa Kazumasa

  Advanced Research Center For Human Sciences Waseda University

• Horikawa Kazumasa

  Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Japan

• Shibata Shigenobu

  Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Japan

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• Two Distinct Serotonin Receptors Co-mediate Non-photic Signals to the Circadian Clock

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