Screening for Intestinal Microflora Influencing Superoxide Dismutase Activity in Mouse Cecal Mucosa
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概要
- 論文の詳細を見る
We have suggested that intestinal microflora reduces the activity of the antioxidant enzyme superoxide dismutase (SOD) in the mouse cecal mucosa. In this study, gnotobiotic mice were used to examine the species of intestinal microflora influencing SOD activity in the cecal mucosa. The total SOD activity in the cecal mucosa of each germ-free (GF), gnotobiotic mouse with Escherichia coli, Lactobacillus and Bacteroides was significantly higher than that in the cecal mucosa of gnotobiotic mice with chloroform-treated feces (CHF), conventionalized (CVz) mice and conventional (CV) mice (P<0.05). In addition, CuZnSOD mRNA expression showed similar tendencies. Our results suggest that the antioxidant defense status in the cecal mucosa is influenced by CHF inoculation.
- 公益社団法人 日本獣医学会の論文
著者
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Amao Hiromi
Laboratory Of Experimental Animal Science Nippon Veterinary And Animal Science University
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Dobashi Yuu
Laboratory Of Experimental Animal Science Nippon Veterinary And Animal Science University
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Tohei Atsushi
Laboratory Animal Research Center, Dokkyo Medical University
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ITOH Kikuji
Japan SLC, Inc.
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TOHEI Atsushi
Laboratory of Experimental Animal Science, Nippon Veterinary and Life Science University
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- Screening for Intestinal Microflora Influencing Superoxide Dismutase Activity in Mouse Cecal Mucosa