Characterization and clinical implications of myeloid-derived suppressor cells in head and neck cancer

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Myeloid-derived suppressor cells (MDSC) represent a heterogeneous population and have the potential to suppress immune responses via diverse mechanisms including the production of immunosuppressive cytokines, arginase I, reactive oxygen species, and nitric oxide. Due to the lack of specific markers, human MDSC are still poorly defined. Recent studies suggest that in head and neck cancer, abnormal accumulation of MDSC in peripheral blood and tumor sites might contribute as an important mechanism of tumor immune evasion. This article reviews the characterization and immune suppressive mechanisms mediated by MDSC. Moreover, clinical implications in patients with head and neck cancer, as well as the development of novel strategies to efficiently overcome immune suppression by MDSC are also discussed.
日本耳鼻咽喉科免疫アレルギー学会の論文