THE EVALUATION OF EFFECTIVENESS AND SAFETY OF PEPPERMINT OIL SOLUTION AS AN ANTISPASMODIC AGENT DURING ENDOSCOPIC SUBMUCOSAL DISSECTION

概要

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Although hyoscine butyl bromide and glucagon are often used as antispasmodic drugs during esophagogastroduodenoscopy, these agents may cause adverse effects. Recently, it was reported that peppermint oil solution (PO) was very effective and had few side effects. We clarified the effectiveness and safety of PO as an antispasmodic for ESD that is a time-consuming and complex endoscopic treatment. The antispasmodic scores, frequency of other additional drugs, the sustained antispasmodic time and adverse events associated with PO were evaluated. The average of the antispasmodic score in a total of 165 ESD procedures was 4.66 (1 to 5, where 5 represent no spasm). One-point-nine percent of all cases required additional antispasmodic agents, and the average of the sustained time was 44.8 min. There was no severe adverse event for PO during ESD procedures. In conclusion, PO was useful and safe as an antispasmodic during ESD.