Six Cases of Colorectal and Small Bowel Cancer Associated with Crohn's Disease

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Although the number of reports of colorectal and small bowel cancer associated with Crohn's disease (CD) has been increasing, there have been few studies on the characteristics and clinical outcomes of CD-associated cancer. We herein report six cases of colorectal and small bowel cancer associated with Crohn's disease treated from January 2001 to May 2011. Their average age was 40.0 years. All of them had been suffering from Crohn's disease for more than 10 years. There was one patient with stage I cancer, three patients with stage II, and one patient with stage IV. We were able to perform a curative resection in five cases, and disease recurrence was observed in one patient. The recent remarkable progress in medical treatments has contributed to improvements in the clinical outcome; however, careful surveillance for the occurrence of CD-associated cancer is necessary. Surveillance for the early diagnosis of neoplastic lesions can enable treatment and thus a better outcome.