1H NMR Spectroscopic Quantification of Plasma Metabolites in Dialysate during Hemodialysis
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概要
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We used 1H nuclear magnetic resonance (NMR) spectroscopy to assess metabolic responses in patients undergoing hemodialysis (HD). We collected 71 samples of plasma and dialysate from 10 patients before, during, and after HD. We used the dialysate as a possible substitute for blood plasma to quantify small metabolites by 1H NMR. We confirmed TSP (sodium 3-(trimethylsilyl) propionate 2, 2, 3, 3-d4) as a reference of NMR intensity in dialysate. We examined TSP sensitivities in various dialysate spectra and the correlation between signal intensities and added quantities of TSP. We used integrations of signal areas on 1H NMR spectra of plasma and dialysate to quantify concentrations of creatinine, lactate, alanine, and valine and calculate their ratios between plasma and dialysate. The ratios of metabolites in plasma to dialysate were 3.2±0.4 (creatinine), 3.6±0.5 (valine), 3.8±0.7 (alanine), and 4.0±0.8 (lactate) mM (mean±standard deviation [SD]). The broader distributions of ratios in levels of lactate and alanine suggested their de novo production during the HD session. Estimation of blood metabolite levels using dialysate is useful for quantitative analysis of metabolic status in blood during HD.
著者
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Fujiwara Masako
Graduate School of Pharmaceutical Sciences, Tohoku University
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Ando Itiro
Graduate School of Pharmaceutical Sciences, Tohoku University
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Imai Yutaka
Graduate School of Pharmaceutical Sciences, Tohoku University
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Imai Yutaka
Graduate School Of Pharmaceutical Sciences Tohoku University
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OGUMA Shiro
Koujinkai Nagamachi Clinic
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SEKINO Hiroshi
Koujinkai Central Clinic
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Sato Hiroshi
Graduate School of Agriculture, Hokkaido University
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SEKINO Hiroshi
Koujinkai Hemodialysis Clinic
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TAKEUCHI Kazuhisa
Graduate School of Pharmaceutical Sciences, Tohoku University
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