Oxaliplatin-induced Acute Thrombocytopenia: A Case Report and Review of the Literature
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概要
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We herein report the case of a 77-year-old woman who developed acute thrombocytopenia during the 23rd cycle of modified FOLFOX therapy. She developed a hypersensitivity reaction with nasal bleeding. The chemotherapy infusion was immediately discontinued. The patient's symptoms resolved with discontinuation of chemotherapy and the administration of supportive therapy. A complete blood count showed severe thrombocytopenia, and oxaliplatin-induced thrombocytopenia was diagnosed. The patient was admitted to the hospital, and the thrombocytopenia was corrected with a platelet transfusion followed by prednisolone. She was discharged after one week without requiring additional platelet transfusions. With the widespread use of oxaliplatin, the risk of oxaliplatin-induced acute thrombocytopenia should be considered an acute onset hematological emergency.
著者
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MASUYA Masahiro
Department of Second Internal Medicine, Mie University School of Medicine
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Imai Hiroshi
Emergency and Critical Care Medicine, Kitasato University School of Medicine
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Katayama Naoyuki
Department Of Advanced Materials Science University Of Tokyo
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Nakase Kazunori
Department Of Hematology And Oncology Mie University Graduate School Of Medicine
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Suzuki Kei
Department Of Hematology And Oncology Mie University Graduate School Of Medicine
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Fujioka Masaki
Emergency and Critical Care Center, Mie University Hospital, Japan
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Nakase Kazunori
Department of Hematology and Oncology, Mie University Graduate School of Medicine, Japan
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Oda Hiroyasu
Department of Hematology and Oncology, Mie University Graduate School of Medicine, Japan
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Sugawara Yumiko
Department of Hematology and Oncology, Mie University Graduate School of Medicine, Japan
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Masuya Masahiro
Department of Hematology and Oncology, Mie University Graduate School of Medicine, Japan
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