Demographic Features of Japanese Patients with Sporadic Inclusion Body Myositis: A Single-center Referral Experience

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概要

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• Objective The incidence of sporadic inclusion body myositis (sIBM) in the Japanese population has increased, and some researchers have suggested that race and genetic background may influence the clinical features of the disease. The aim of this study was to clarify the demographic features of Japanese patients with sIBM. Methods We retrospectively evaluated the demographic features of consecutive patients who were referred to our institution between 1995 and 2011 for diagnostic muscle biopsies and who subsequently were diagnosed to have sIBM. Results Seventy-three patients comprising 54 men and 19 women received a diagnosis of sIBM during the study period. The patients were divided into two groups based on the date of diagnosis (before and including 2002, and after 2002). The annual number of patients who received a diagnosis of sIBM increased significantly from 3.6±1.6 (mean ± SD) before and including 2002 to 4.9±3.1 (mean ± SD) after 2002 (p<0.05), whereas the annual number of patients who received a diagnosis of polymyositis (PM) or dermatomyositis (DM) remained consistent from 1995 to 2011. The ratio of PM and DM to sIBM was 7.6 during the period from 1995 to 2002 and 5.5 during the period from 2003 to 2011. However, the age-adjusted annual number of patients newly diagnosed with sIBM did not increase significantly after 2002. Conclusion The number of Japanese patients with sIBM appears to have increased in recent years; however, the characteristics of the patients have not changed. Considering the increased size of the elderly population, prolonged lifespans could explain the demographic movement of sIBM in Japan.

著者

• Matsuo Koji

  Department Of Cardiology And Nephrology Mie University Graduate School Of Medicine

• Kimura Seigo

  Department Of Neurology Nagoya University Graduate School Of Medicine

• Watanabe Hirohisa

  Department Of Neurology Nagoya Daini Red Cross Hospital

• KOIKE Haruki

  Department of Neurology, Nagoya University School of Medicine

• Fujikake Akifumi

  Department Of Internal Medicine Division Of Neurology Aichi Medical University School Of Medicine

• Katsuno Masahisa

  Department Of Neurology Nagoya University Graduate School Of Medicine

• Nakanishi Hirotaka

  Department Of Medicine Teikyo University

• SOBUE Gen

  Department of Internal Medicine, Aichi Medical University School of Medicine

• Tanaka Fumiaki

  Department of Clinical Neurology and Stroke Medicine, Yokohama City University, Japan

• Noda Tomoko

  Department of Neurology, Nagoya University Graduate School of Medicine, Japan

• Doyu Manabu

  Department of Internal Medicine, Division of Neurology, Aichi Medical University, Japan

• Nakanishi Hirotaka

  Department of Neurology, Nagoya University Graduate School of Medicine, Japan

• Matsuo Koji

  Department of Neurology, Okazaki City Hospital, Japan

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