Infective Endocarditis Caused by Enterococcus faecalis treated with Continuous Infusion of Ampicillin without Adjunctive Aminoglycosides
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概要
- 論文の詳細を見る
Aminoglycosides are useful antimicrobial agents for treating infective endocarditis; however, they occasionally cause troublesome side effects, such as nephrotoxicity and ototoxicity. We herein report a case of infective endocarditis caused by Enterococcus faecalis that was treated successfully with continuous infusion of ampicillin without adjunctive aminoglycosides. The serum ampicillin concentrations were higher than the minimal inhibitory concentration for the target strain. Although the use of ampicillin monotherapy is currently avoided because double β-lactam therapy is reportedly more effective, continuous penicillin administration remains an effective therapeutic choice for treating infective endocarditis.
著者
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Maeda Koichi
Center for Infectious Diseases, Nara Medical University
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Konishi Mitsuru
Center For Infectious Diseases Nara Medical University
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Kasahara Kei
Center For Infectious Diseases Nara Medical University
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Uno Kenji
Center For Infectious Diseases Nara Medical University School Of Medicine
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Mikasa Keiichi
Center For Infectious Diseases Nara Medical University
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Yonekawa Shinsuke
Center For Infectious Diseases Nara Medical University
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Nakagawa Chiyo
Center For Infectious Diseases Nara Medical University
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Ogawa Taku
Center For Infectious Diseases Nara Medical University
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Sato Masatoshi
Center for Infectious Diseases, Nara Medical University, Japan
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Nakagawa Chiyo
Center for Infectious Diseases, Nara Medical University, Japan
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