Amphotericin B-induced Nephrogenic Diabetes Insipidus in a Case of Cryptococcemia
スポンサーリンク
概要
- 論文の詳細を見る
A 66-year-old woman with malignant lymphoma became neutropenic during chemotherapy and developed cryptococcemia. After amphotericin B had been commenced, she developed significant hypokalemia and polyuria, though her renal function remained stable. The laboratory findings showed no evidence of renal tubular acidosis. With vigorous water and potassium replacement, amphotericin B had been continued until the cumulative dose reached 2.5 g. After the cessation of amphotericin B, the hypokalemia and polyuria resolved promptly. Based on theses findings, she was diagnosed as nephrogenic diabetes insipidus with hypokalemia and without renal tubular acidosis due to amphotericin B. This complication is usually reversible, and vigorous water and potassium replacement may allow completion of treatment by amphotericin B, though careful monitoring of body water balance and renal function is of importance.
- 社団法人 日本内科学会の論文
- 2005-05-01
著者
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Kasahara Kei
Center for Infectious Diseases, Nara Medical University
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Konishi Mitsuru
Center for Infectious Diseases, Nara Medical University
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Mikasa Keiichi
Center for Infectious Diseases, Nara Medical University
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Konishi Mitsuru
Center For Infectious Diseases Nara Medical University School Of Medicine
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Konishi Mitsuru
Center For Infectious Diseases Nara Medical University
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Kasahara Kei
Second Department Of Internal Medicine Nara Medical University
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Kasahara Kei
Center For Infectious Diseases Nara Medical University
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Morii Takeshi
Second Department Of Internal Medicine Nara Medical University
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Uno Kenji
Center for Infectious Diseases, Nara Medical University
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Yoshimoto Eiichiro
Center for Infectious Diseases, Nara Medical University
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Maeda Koichi
Department of General Medicine, Nara Medical University
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Kimura Hiroshi
Second Department of Internal Medicine, Nara Medical University
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Uno Kenji
Center For Infectious Diseases Nara Medical University School Of Medicine
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FUJITA Yukio
Second Department of Internal Medicine, Nara Medical University
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MURAKAWA Koichi
Division of Central Clinical Laboratory, Nara Medical University
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AMANO Itsuto
Second Department of Internal Medicine, Nara Medical University
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Amano Itsuto
Second Department Of Internal Medicine Nara Medical University
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Yoshimoto Eiichiro
Center For Infectious Diseases Nara Medical University
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Fujita Yukio
Second Department Of Internal Medicine Nara Medical University
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Maeda Koichi
Department Of General Medicine And Clinical Investigation Nara Medical University
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Mikasa Keiichi
Center For Infectious Diseases Nara Medical University
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Kimura Hiroshi
Second Department Of Internal Medicine Nara Medical University
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Maeda Koichi
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
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